chr22_3

cmsearch-Rfam

Family :

IRES_n-myc

Id:

RF00226

Type:

Cis-reg; IRES;

Taxonomy:

Eukaryota;

Ontology:

GO:0043022 ribosome binding

Description:

This family represents the n-myc internal ribosome entry site (IRES). The myc family of genes when
expressed are known to be involved in the control of cell growth, differentiation and apoptosis.
n-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are
recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent
translation pathway [1].

Score:

22.6

E-value:

0.00021

From sequence:

212915

To sequence:

213072

Alignments:

                                                             v        v                                           NC
                 :::::::::::::..:::::::::(((,,,,,,,,,,,,,,<<<<<~~~~~~>>>>>,,,,,,,,,,,,,,,,,,,,,,,,,<<<___________ CS
  RF00226      1 cuCuaaAcGaGcu..ggGuaGauagGGaGggauacugagAACugcg*[36]*cgcaGaauGauuggGcaaCcuGguuagaccggGCcCCCAuuGcC 124   
                 ++C+A+A G+G++   GG++G+++GGG+GGGA + + ++AAC:: G      C ::GAA GA+ G   AAC+UG+   ++     C  C A  G  
    chr22 212915 AACAAGAAGCGGGugAGGGGGGGGGGGGGGGAACAGAGCAACUACG*[ 5]*CAUGGAAGGAAGGAAAAACAUGAAAUAUAA---CAUCUAGCGU- 213005
                 *******9998761156777778888889999999********976...8..6789***************99998877665...3333333333. PP

                                                                     NC
                 ____>>>,,,,,,,,,,,,,,,,,,,,,,)))-------~~~~~~~::::: CS
  RF00226    125 uAuCCccagacuCuaGCgCaGaaUcgcCuCCcuaUcCCc*[154]*CCAUG 322   
                 +AUC   A+AC C  GC C+G++UC CC CCC + CCC        CCA G
    chr22 213006 CAUC---ACACACACGCACCGUUUCUCCCCCCCCCCCCU*[ 26]*CCAAG 213072
                 3444...99*******************99999888754....9..***** PP

RNAfold
>chr22_3
UCCAAGCGGGGGGAGAGGGGGUGCAAAGAGAGGGAGAUGAAGCCGGUGAU
AAGGUAAGUGAAGACCCAUGGAGAGGGUGGCAACAAGAAGCGGGUGAGGG
GGGGGGGGGGGGAACAGAGCAACUACGCAUGGCAUGGAAGGAAGGAAAAA
CAUGAAAUAUAACAUCUAGCGUCAUCACACACACGCACCGUUUCUCCCCC
CCCCCCCUUCCCCGCGUGCUCCUUCAUAGAAGUUCCAAGAAGUGGUGUUC
GCUUCACCCCGCUUAGUUAGCGCGAAGCCUUGCCCCCGACUAGUGGAGCA
GCAAGCAUGCAUGGCAUUCUU
((((((((((((..((((..((((.(((((.(((.(.(((.(((........))).((((((.((((.(((((((((.((((.(.....(((((.((((((((((((((((((((.(.((........(((((.((((.(......................).))))..))))).........)).).)))))))))))))))))))).)))))))))))))))........)))).)....))).))))))))))))).)))..)).))))....)))).)))))).))..))))......((.((((...)))).)). (-124.10)

Length sequence

: 321

Length match:

156