gi_545778205_gb_U000_191

cmsearch-Rfam

Family :

RNaseP_arch

Id:

RF00373

Type:

Gene; ribozyme;

Taxonomy:

Bacteria; Archaea;

Ontology:

GO:0008033 tRNA processingRF00373

Description:

Ribonuclease P (RNase P) is a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well
as chloroplasts and mitochondria. Its best characterised activity is the generation of mature 5'-ends of
tRNAs by cleaving the 5'-leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from
bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e.
it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown
to retain its catalytic function, but is still essential for the catalytic activity of the
holoenzyme. Although the archaeal and eukaryotic holoenzymes have a much greater protein content than the
bacterial ones, the RNA cores from all the three lineages are homologous -- helices corresponding
to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P RNAs.
Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs.

Score:

47.3

E-value:

1.2e-11

From sequence:

3270581

To sequence:

3270222

Alignments:

                                    v vvvvv         v  v                       v  v                              NC
                               [[[-[[[[[[[[[[[[[,,,<<<<<_..................____>>>>>,,,,,,,,,,,,,((((--------((( CS
               RF00373       1 GggAGcggGaGggcgGCUgaCgggcc..................uugagcccGAGGAAAgUCCcCCCaCCauuccgaAggc 63     
                                ::AG :G    ::: : G C  : +                  ++G  :  GAGGAAAGUCC   C:CCAU+  G AGG:
  gi_545778205_gb_U000 3270581 GACAGUCGC---CGCUUCGUCGUCGUccucuucgggggagacggGCGGAGGGGAGGAAAGUCCGGGCUCCAUAGGGCAGGG 3270504
                               *****8655...5555555555554455566688888777666555558899***************************** PP

                                                 v          v      v                                 v           NC
                               ((<<<<<_____>>>>><<<<<____>>>>><<---<<<<.------------~~~~~~-------->>>>-->>)))))) CS
               RF00373      64 ggcCggcGcAAGgccGgggcgcGAGAgcgccGGCacuggc.ACAGAAACGAcA*[68]*aUGaAACGgccaAuCCccgccG 205    
                               :GCC:G: +A G:C:GGG :G:GA A:C:+CG:C + : C ACAGA A  A+A       UG+ ACGG : A :CC::CCG
  gi_545778205_gb_U000 3270503 UGCCAGGUAACGCCUGGG-GGGGAAACCCACGACCAGUGCaACAGAGAGCAAA*[80]*GUGGCACGGUAAACUCCACCCG 3270350
                               *****************9.888899********98888885788888877777...4..46667999999999******** PP

                                                                                                        v        NC
                               ))),,,<<<<---...<<<<<_________________....>>>>>----->>>>,,,,,,,,,,,,]]]]]]....... CS
               RF00373     206 GuGCAAGuccaaa...gcgccgaugAgagucagcauga....ggcgcugguaggaCGCUuAGcCGAAUGCcgcc....... 272    
                               G:GCAA::CCAAA   G:G:: AU AG + C+GC  G     ::C:C GGUAGG::GCUU   C A U: :::+       
  gi_545778205_gb_U000 3270349 GAGCAAGGCCAAAuagGGGUUCAUAAGGUACGGCCCGUacugAACCCGGGUAGGCUGCUUGAGCCAGUGAGCGAuugcugg 3270269
                               ************9**98888866666666555555444567799999***********998888888866665599***** PP

                                                                     vv vv v      NC
                               ..................-------------------.]]-]]]]]-]]] CS
               RF00373     273 ..................augAACAGAAGGgGGcUUA.CuCCccgCAccC 303    
                                                  +  ACAGAA   GGCUUA C    : CA:: 
  gi_545778205_gb_U000 3270268 ccuagaugaaugacugucCACGACAGAACCCGGCUUAuCG---GUCAGUU 3270222
                               ****************988889***************888...78***** PP

RNAfold
>gi_545778205_gb_U000_191
ACUGACCGAUAAGCCGGGUUCUGUCGUGGACAGUCAUUCAUCUAGGCCAG
CAAUCGCUCACUGGCUCAAGCAGCCUACCCGGGUUCAGUACGGGCCGUAC
CUUAUGAACCCCUAUUUGGCCUUGCUCCGGGUGGAGUUUACCGUGCCACG
GACUGUUACCAGCCGCGCGGUGCGCUCUUACCGCACCCUUUCACCCUUAC
CUGAUCCCGCUUGCGCGGGCCAUCGGCGGUUUGCUCUCUGUUGCACUGGU
CGUGGGUUUCCCCCCCAGGCGUUACCUGGCACCCUGCCCUAUGGAGCCCG
GACUUUCCUCCCCUCCGCCCGUCUCCCCCGAAGAGGACGACGACGAAGCG
GCGACUGUC
..........(((((((((((((((...)))))...........((((((..........))))))..(((((((.....((((((((((((...)))))....)))))))......)))..)))).(((..(((((.((((((((...((.(((....))))))))))))).)))))..))).......(((........))).(((((....)))))((((.(((((..((((......(((.((((..(.(((....)))))))))))......))))..)))))..))))))))))).))).........((((.((((((..((.....))..)).))))..))))........ (-131.20)

Length sequence

: 359

Length match:

358