gi_545778205_gb_U000_192

cmsearch-Rfam

Family :

RNaseP_bact_a

Id:

RF00010

Type:

Gene; ribozyme;

Taxonomy:

Eukaryota; Bacteria;

Ontology:

GO:0008033 tRNA processingRF00010

Description:

Ribonuclease P (RNase P) is a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well
as chloroplasts and mitochondria. Its best characterised activity is the generation of mature 5'-ends of
tRNAs by cleaving the 5'-leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from
bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e.
it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown
to retain its catalytic function, but is still essential for the catalytic activity of the
holoenzyme. Although the archaeal and eukaryotic holoenzyme s have a much greater protein content than
the bacterial ones, the RNA cores from all the three lineages are homologous -- helices
corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P
RNAs. Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs.

Score:

312.6

E-value:

1.7e-101

From sequence:

3270592

To sequence:

3270216

Alignments:

                                                    v                                    v                       NC
                               {{{{{{{{{{{{{{{{{{,<<<<<<<<<__..................____>>>>>>>>>,,,,,,,,,,,,,[[[[--- CS
               RF00010       1 cgagccggccgggcggucGCgcccccccuu..................aaaagggggggcGAGGAAAGUCCGGgCUcCAuA 63     
                               ::A C:G:CC:G:C:GUCGC: C::C::                    A   ::G::G :GAGGAAAGUCCGGGCUCCAUA
  gi_545778205_gb_U000 3270592 GAAGCUGACCAGACAGUCGCCGCUUCGUCGucguccucuucgggggagACGGGCGGAGGGGAGGAAAGUCCGGGCUCCAUA 3270512
                               ****************************999999999999999999998888***************************** PP

                                                                                                       v         NC
                               -----[[[[[<<<<<_____>>>>><<<<<____>>>>->((---(((((,,,,,,,,,,,,<<<<<..<<<<<<....._ CS
               RF00010      64 GggCAggguGccgGgUAACgcCcggcggggGugAccccAgGGAaAGugCcACAGAAAauAgACCgCc..cgcccc.....u 137    
                               GGGCAGGGUGCC:GGUAACGCC:GG:GGG G +A CCCA:G:  AGU:C:ACAGA+A++A+ACC:CC  :G  CC      
  gi_545778205_gb_U000 3270511 GGGCAGGGUGCCAGGUAACGCCUGGGGGG-GAAA-CCCACGACCAGUGCAACAGAGAGCAAACCGCCgaUGGCCCgcgcaA 3270433
                               **************************665.7777.5668****************************88666666777765 PP

                                    v                                                                            NC
                               ___>>>>>>>>>-->>,,,,,,,<<<<<<_______>>>>>><<<<<<<<<____>>>.>>>>>->,,)))--))))]]]] CS
               RF00010     138 uauggggcggGcAAGGGUGAAAaGGugcgGUAAGAGcgcaCCGcgcccccGGuaACgg.gggcgGCuugGcAAaCCCCacc 217    
                                  GG  C:GG:AAGGGUGAAA GGUGCGGUAAGAGCGCACCGC C::C:GGUAAC:G ::G GGC+ :G:AAAC:CCACC
  gi_545778205_gb_U000 3270432 GCGGGAUCAGGUAAGGGUGAAAGGGUGCGGUAAGAGCGCACCGCGCGGCUGGUAACAGuCCGUGGCACGGUAAACUCCACC 3270352
                               555666677*************************************************99********************* PP

                                                                                                                 NC
                               ]]]]],,,<<<<------<<<<<<-----<<<<<_____>>>>>->>>>>>----->>>>,,,,,,<<<<<<<<____>>> CS
               RF00010     218 cGgAGCAAggccAAAUAGGggcgcauuuacgggcugcucgcccgagcgccCGGGUaggccGCUuGAGccggccgGuAAcgg 298    
                               CGGAGCAA:GCCAAAUAGGGG::CAU++  G::C+GC+CG::C  G::CCCGGGUAGGC:GCUUGAGCC:G: :G++A: :
  gi_545778205_gb_U000 3270351 CGGAGCAAGGCCAAAUAGGGGUUCAUAA-GGUACGGCCCGUACU-GAACCCGGGUAGGCUGCUUGAGCCAGUGAGCGAUUG 3270273
                               ***************************8.99999*****99999.************************************ PP

                                                                                                     NC
                               >>>>>,,,,,,,,,,}}}}}}}-------------------------------}-}}}}}}}}}}:::: CS
               RF00010     299 ccggCCuAGAugAAUgaccgccaucuauuuaaauuuuaACAGAAcCCGGCUUAcaggccggcucgucau 367    
                               C:GGCCUAGAUGAAUGAC:G:C++C            +ACAGAACCCGGCUUA: GG:C:G U::+C+U
  gi_545778205_gb_U000 3270272 CUGGCCUAGAUGAAUGACUGUCCAC------------GACAGAACCCGGCUUAUCGGUCAGUUUCACCU 3270216
                               ************************9............******************************** PP

RNAfold
>gi_545778205_gb_U000_192
GGUGAAACUGACCGAUAAGCCGGGUUCUGUCGUGGACAGUCAUUCAUCUA
GGCCAGCAAUCGCUCACUGGCUCAAGCAGCCUACCCGGGUUCAGUACGGG
CCGUACCUUAUGAACCCCUAUUUGGCCUUGCUCCGGGUGGAGUUUACCGU
GCCACGGACUGUUACCAGCCGCGCGGUGCGCUCUUACCGCACCCUUUCAC
CCUUACCUGAUCCCGCUUGCGCGGGCCAUCGGCGGUUUGCUCUCUGUUGC
ACUGGUCGUGGGUUUCCCCCCCAGGCGUUACCUGGCACCCUGCCCUAUGG
AGCCCGGACUUUCCUCCCCUCCGCCCGUCUCCCCCGAAGAGGACGACGAC
GAAGCGGCGACUGUCUGGUCAGCUUC
...(((.((((((((((((((((((((((((...)))))...........((((((..........))))))..(((((((.....((((((((((((...)))))....)))))))......)))..)))).(((..(((((.((((((((...((.(((....))))))))))))).)))))..))).......(((........))).(((((....)))))((((.(((((..((((......(((.((((..(.(((....)))))))))))......))))..)))))..))))))))))).))..........((((.((((((..((.....))..)).))))..))))....)))).)))))).))) (-141.80)

Length sequence

: 376

Length match:

375