gi_545778205_gb_U000_193

cmsearch-Rfam

Family :

RNaseP_bact_b

Id:

RF00011

Type:

Gene; ribozyme;

Taxonomy:

Eukaryota; Bacteria;

Ontology:

GO:0008033 tRNA processingRF00011

Description:

Ribonuclease P (RNase P) is a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well
as chloroplasts and mitochondria. Its best characterised activity is the generation of mature 5'-ends of
tRNAs by cleaving the 5'-leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from
bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e.
it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown
to retain its catalytic function, but is still essential for the catalytic activity of the
holoenzyme. Although the archaeal and eukaryotic holoenzyme s have a much greater protein content than
the bacterial ones, the RNA cores from all the three lineages are homologous -- helices
corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P
RNAs. Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs.

Score:

40.1

E-value:

4.2e-09

From sequence:

3270588

To sequence:

3270227

Alignments:

                                                v                                      v                         NC
                               :::{{{{{{{{{{{,<<<<<<____......................_~~~~~>>>>>>,,,,,,,,,,,,,{{{{{<    CS
               RF00011       1 auuuucgGguaaucGCugcgguauu......................u*[3]*ccgcaGAGGAAAGUCCAuGCucGCA    54     
                                U ::C:G::A:UCGC: C:   U                              :G :GAGGAAAGUCC    :::CA
  gi_545778205_gb_U000 3270588 CUGACCAGACAGUCGCCGCUUCGUCgucguccucuucgggggagacgG*[3]*GAGGGGAGGAAAGUCCGG-GCUCCA    3270514
                               *****************9998776655655555555555555555554..5..8999************85.677795    PP

                                                                                              v              v   NC
                               ~~~~~~>,,,,,.[[[[[<<<<<<__________>>>>>><<<<<<<____>>>>>>->((,<<<<----~~~~~~>>>>, CS
               RF00011      55 *[16]*UAGUGU.UcGuGcugggcgAAauAAUAAgcccagGcAggcguuuacgccUgACGGCgggcaAAa*[28]*gcccU 166    
                                     UAG G  ::GUGC::GG: A        :CC::GG::G     +A   C::ACG:C: G:  AA      :C :U
  gi_545778205_gb_U000 3270513 *[ 0]*UAGGGCaGGGUGCCAGGUAA-------CGCCUGGGGGG---GAAA---CCCACGACCAGUGCAA*[56]*GCGGU 3270402
                               ......4888855***********33.......3*******975...6777...579*****98877666...9..55566 PP

                                    v               v v              v v              v                          NC
                               ,,,,<<<<<------------<<<<<<<<____>>>>>>>>--------->>>-->>))]]]]]}}}}},,,<<<______ CS
               RF00011     167 gAAAGUgCCACAGuGACGaagcuucucugGAAAcagagaagGUGgAACGcGGuAAACCCCaCgAGCgaGaAACCcAAAuUU 247    
                                A AG GC AC     CG      : CUGG AACAG :   GUGG ACG  GUAA C:CCAC::G::: AA  CCAAAU  
  gi_545778205_gb_U000 3270401 AAGAGCGC-AC-----CGCG---CGGCUGGUAACAGUC--CGUGGCACG--GUAAACUCCACCCGGAGCAAGGCCAAAUAG 3270334
                               66666665.23.....3333...466788888888865..477888886..8************97777777777888775 PP

                                                                                                                 NC
                               ____~~~~~>>>,,,<<<<<~~~~~~>>>>><<<<<<_..............._~~~~~>>>>>>,,,,,,,,}}}}}}}, CS
               RF00011     248 UGGU*[1]*gGGGaAcccgg*[21]*ccgggacggccu...............u*[3]*ggccguAGAuAgAUgauuacCa 322    
                                GGU     GG  +  CC:G      C:GG A:G:                  +       :C:UAGAU +AUGA:U::C 
  gi_545778205_gb_U000 3270333 GGGU*[6]*GGUACGGCCCG*[ 9]*CGGGUAGGCUGCuugagccagugagcgA*[4]*UGGCCUAGAUGAAUGACUGUCC 3270250
                               5444..4..54444443333...3..3344444444333333333333665552..3..556789***************9 PP

                                                                            NC
                               <<<<<<<<<_____>>>>>>>>>,,,,,,,,,,,,,,,,}-}}} CS
               RF00011     323 ccgccgggcauuuagcccggcggaACAgAACaUGGCUUAcagaa 366    
                                           +           ACAGAAC  GGCUUA: G::
  gi_545778205_gb_U000 3270249 ------------AC---------GACAGAACCCGGCUUAUCGGU 3270227
                               ............88.........********************* PP

RNAfold
>gi_545778205_gb_U000_193
GACCGAUAAGCCGGGUUCUGUCGUGGACAGUCAUUCAUCUAGGCCAGCAA
UCGCUCACUGGCUCAAGCAGCCUACCCGGGUUCAGUACGGGCCGUACCUU
AUGAACCCCUAUUUGGCCUUGCUCCGGGUGGAGUUUACCGUGCCACGGAC
UGUUACCAGCCGCGCGGUGCGCUCUUACCGCACCCUUUCACCCUUACCUG
AUCCCGCUUGCGCGGGCCAUCGGCGGUUUGCUCUCUGUUGCACUGGUCGU
GGGUUUCCCCCCCAGGCGUUACCUGGCACCCUGCCCUAUGGAGCCCGGAC
UUUCCUCCCCUCCGCCCGUCUCCCCCGAAGAGGACGACGACGAAGCGGCG
ACUGUCUGGUCAGCU
((((((((((((((((((((((...)))))...........((((((..........))))))..(((((((.....((((((((((((...)))))....)))))))......)))..)))).(((..(((((.((((((((...((.(((....))))))))))))).)))))..))).......(((........))).(((((....)))))((((.(((((..((((......(((.((((..(.(((....)))))))))))......))))..)))))..))))))))))).))..........((((.((((((..((.....))..)).))))..))))....)))).)))).... (-136.50)

Length sequence

: 365

Length match:

360